MidwestSports.Net ranks the top 10 football teams in the midwest region in NCAA Division II and NAIA for Sept. 16, 2018.
DIVISION II
| Ranking | Team | Record | Previous | Last Week / This Week |
| 1 | Northwest Missouri | (3-0) | 1 | Def. Missouri Southern, 63-0 Sept. 22 at Central Oklahoma |
| 2 | Southern Arkansas | (3-0) | 2 | Def. Southwestern Okla. 36-12 Sept. 22 vs. Northwestern Okla. |
| 3 | Pittsburg State | (3-0) | 3 | Def. Northeastern State, 45-7 Sept. 22 vs. Neb.-Kearney |
| 4 | Ouachita | (3-0) | 4 | Def. Southeastern Okla., 32-16 Sept. 22 vs. East Central |
| 5 | Central Missouri | (2-1) | 6 | Def. Missouri Western, 51-14 Sept. 22 at Washburn |
| 6 | Fort Hays State | (2-1) | 7 | Def. Missouri Western, 30-24 Sept. 22 at Missouri Southern |
| 7 | Harding | (2-1) | 8 | Def. Southern Nazarene, 42-0 Sept. 22 vs. Oklahoma Baptist |
| 8 | Emporia State | (2-1) | NR | Def. Nebraska-Kearney, 20-17 Sept. 22 vs. Lindenwood |
| 9 | Chadron State | (2-1) | NR | Def. Fort Lewis, 31-21 Sept. 22 at Colorado Mines |
| 10 | Missouri S&T | (2-1) | 5 | Lost to Drake, 52-12 Sept. 22 at Tuskegee |
NAIA
| Ranking | Team | Record | Previous | Last Week / This Week |
| 1 | Morningside | (3-0) | 1 | Def. Dakota Wesleyan, 66-13 Sept. 22 vs. Briar Cliff |
| 2 | Northwestern (Iowa) | (3-0) | 2 | Def. Midland, 49-20 Sept. 22 at Dakota Wesleyan |
| 3 | Evangel | (4-0) | 4 | Def. Peru State, 35-13 Sept. 22 vs. Culver-Stockton |
| 4 | Langston | (1-0) | 3 | Vs. Southern, canceled – lightning Sept. 22 vs. SAGU |
| 5 | Kansas Wesleyan | (3-0) | 7 | Def. Sterling, 42-7 Sept. 22 vs. Ottawa |
| 6 | Ottawa | (3-0) | 8 | Def. Bethany, 42-35 Sept. 22 at Kansas Wesleyan |
| 7 | Avila | (3-0) | 9 | Def. Bethel, 35-29 Sept. 22 vs. St. Mary |
| 8 | Grand View | (2-1) | NR | Def. Central Methodist, 47-27 Sept. 29 at Missouri Valley |
| 9 | Midland | (2-1) | 6 | Lost to Northwestern, 49-20 Sept. 22 at Concordia |
| 10 | Benedictine | (2-1) | 10 | Idle Sept. 22 vs. MidAmerica Nazarene |